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Polynucleotide Skin Regeneration

Strengthen, hydrate and rejuvenate skin naturally with regenerative injectables.

Prices from £375

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Polynucleotide Treatment

Polynucleotides are an advanced regenerative injectable treatment designed to improve skin quality at a cellular level. Rather than adding volume or altering facial shape, polynucleotides work by stimulating the skin’s natural repair processes, helping to restore strength, elasticity and hydration from within.

This treatment is particularly effective in delicate areas such as the under-eye, where the skin is thin and prone to fine creasing, shadowing and a tired appearance. By encouraging collagen production and improving micro-circulation, polynucleotides help to smooth fine lines, brighten dark circles and improve overall skin texture. The result is a more refreshed, rested look, without heaviness or swelling.

While the under-eye area is the most popular starting point, polynucleotides can also be used on the face, neck, décolletage and hands to improve skin quality in areas showing early signs of ageing or loss of vitality.

For optimal results, a course of three treatments is usually recommended, spaced two to four weeks apart. Improvements develop gradually after each session, with results typically lasting between six and twelve months. A single maintenance treatment can then be performed to prolong and sustain the benefits.

At The Blackheath Clinic, all polynucleotide treatments are performed by experienced medical professionals following a detailed consultation to ensure the treatment is tailored to your individual skin needs and goals.

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Skin before polynucleotides skin treatment by Blackheath Clinic

Is this treatment for me?

Polynucleotide treatment may be suitable if you are noticing:

  • Loss of skin quality, hydration or elasticity over time

  • Fine lines, uneven texture or early signs of ageing

  • Skin that looks tired, dull or less resilient overall

  • Crepey or thinning skin on the face, neck, décolletage or hands
Skin after polynucleotides skin treatment by Blackheath Clinic

What can I expect?

Most people find polynucleotide treatment straightforward.

  • Mild swelling is common, settling within 24 to 72 hours

  • A course of three treatments spaced two to four weeks apart

  • Skin quality improves gradually, with smoother texture and better hydration

  • Results develop over time and usually last six to twelve months

Our Method

Doctor consultation before polynucleotides skin treatment

Step one

Comprehensive Consultation

Your journey begins with a detailed medical and aesthetic consultation. We take the time to understand your medical history, skin concerns and treatment goals, ensuring polynucleotide therapy is clinically appropriate for you.

Your skin is carefully assessed to evaluate quality, texture and areas that may benefit most from regenerative treatment. With your consent, medical photographs may be taken to support treatment planning and accurately track progress over time.

Doctor explaining how polynucleotides skin treatment works
Step Two

Treatment Planning

Polynucleotide treatment is tailored to your individual skin needs rather than a one-size-fits-all approach. Your clinician will create a bespoke plan based on the areas being treated, skin condition and desired outcomes.

We will explain how polynucleotides work, which areas are likely to benefit most, and how the treatment will be delivered to achieve natural, balanced results aligned with your goals.

Doctor clean skin before polynucleotides skin treatment
Step Three

Preparation & Final Checks

On the day of treatment, the skin is cleansed thoroughly using a gentle, medical-grade cleanser to ensure a hygienic and safe procedure. Arriving without makeup can help streamline this step.

Before proceeding, we reconfirm your treatment plan, answer any final questions and ensure you are comfortable to continue.

Doctor applying injection for polynucleotides skin treatment
Step Four

Treatment & Results

The treatment itself typically takes 10–15 minutes, depending on the areas treated. Most patients find the procedure well tolerated, experiencing only brief, mild discomfort during injection.

Small bumps or mild redness at the injection sites are common and usually settle within a short period. Improvements in skin quality develop gradually over the following weeks, with optimal results seen after completion of the recommended treatment course.

As a patient of The Blackheath Clinic, you will also receive personalised guidance on medical-grade skincare to support and prolong your results, informed by your complimentary Zemits VeraFace 12-factor AI skin analysis.

Caring For Your Skin

Pre-care

  • Avoid ibuprofen, aspirin, omega-3 fish oil and high-dose vitamin E for one week if safe for you

  • Skip retinoids, acids and eye-area waxing or threading for two days before

  • Avoid alcohol for 24 hours before

  • Arrive with clean skin and no eye makeup

Post-care

  • Expect mild puffiness for 24 to 72 hours. Cool compresses can help with this

  • Avoid rubbing or massaging the area for 48 hours, and avoid makeup until the next day

  • Avoid strenuous exercise, saunas, steam rooms and hot yoga for 24 to 48 hours

  • Keep skincare gentle for 48 hours and use SPF daily

  • Book your future sessions as advised to build results

Your skin, your plan.

We look forward to welcoming you to the Blackheath Clinic, where a considered consultation is the first step to beautifully natural results.
Call: 0203 668 2187

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Other Treatments Our Patients Explore

Under-Eye Restoration
Skin Boosters
Volume Restoration

Our Aesthetics Team

Dr Mihaela Plugaru - Lead Aesthetic Doctor at Blackheath Clinic

Dr Mihaela Plugaru

Lead Aesthetic Doctor

Mihaela is a medically trained aesthetic doctor with a strong background in facial anatomy and precision techniques. She graduated from the Gr. T. Popa University of Medicine and Pharmacy in Romania, where she developed a deep understanding of surgical and facial procedures before focusing her career on aesthetic medicine.

“Wrinkle treatments should never freeze your personality. My aim is always to soften lines in a way that looks fresh and natural, so you still look like yourself, but just a more rested version.”

Dr Azqa Sohail – Lead Aesthetics Doctor

Your skin, your plan.

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